Thermo Fisher Scientific PI3K p85 alpha Monoclonal Antibody (8-2D-4D)
PI3K p85 alpha 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, ICC/IF, Flow Cytometry에 사용 가능. 인간, 생쥐, 랫드 반응성. Protein G 정제, 0.2 mg/mL 농도, PBS 버퍼에 0.09% sodium azide 포함. 연구용 전용.
- 판매단위
- pk
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 1 publication |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| Flow Cytometry (Flow) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Pig |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8-2D-4D |
| Immunogen | Purified fragment (aa 333–430) of recombinant human PI3K p85 alpha subunit |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_560620 |
Product Specific Information
- Recommended positive controls: Jurkat or A431 cells.
- By Western Blot, this antibody detects a band of approximately 85 kDa, corresponding to the predicted molecular weight of PI3 kinase.
Target Information
Phosphatidylinositol 3-kinase (PIK3) is a signaling protein that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Signaling is initiated when upstream tyrosine kinase receptors or G protein-coupled receptors are bound by their ligands. It binds to activated (phosphorylated) protein-Tyr kinases through its SH2 domain and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
Phosphatidylinositol 3-kinase plays an important role in insulin signaling and metabolism. Mutations in this gene have been associated with insulin resistance, Agammaglobulinemia 7, SHORT syndrome, and Immunodeficiency 36.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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