Thermo Fisher Scientific Ku70/Ku80 Monoclonal Antibody (162)

Applications

Tested Dilution

Publications

Western Blot (WB)

-

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL

-

Immunocytochemistry (ICC/IF)

1:20-1:200

View 2 publications 2 publications

Flow Cytometry (Flow)

0.5-1 µg/test

-

Immunoprecipitation (IP)

-

View 7 publications 7 publications

ChIP assay (ChIP)

-

View 2 publications 2 publications

Neutralization (Neu)

-

View 1 publication 1 publication

Gel Shift (GS)

-

View 5 publications 5 publications

Product Specifications

Published species

Hamster, Human, Mouse, Non-human primate

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

162

Immunogen

Human B cell nuclei from plasmacytoid 2p68 cells. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Ku70/Ku80,uniProtId:P12956-1,ncbiNodeId:9606,antigenRange:1-609,antigenLength:609,antigenImageFileName:MA1-21818_Ku70Ku80_P12956-1_House_mouse.svg,antigenImageFileNamePDP:MA1-21818_Ku70Ku80_P12956-1_House_mouse_PDP.jpeg,sortOrder:1},{targetFamily:Ku70/Ku80,uniProtId:P13010-1,ncbiNodeId:9606,antigenRange:1-732,antigenLength:732,antigenImageFileName:MA1-21818_Ku70Ku80_P13010-1_House_mouse.svg,antigenImageFileNamePDP:MA1-21818_Ku70Ku80_P13010-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_561990

Product Specific Information

MA1-21818 detects Ku70/Ku80 in human, non-human primate, mouse, rat and xenopus laevis samples. It reacts with a conformational epitope of the p70/p80 dimer, which is destroyed during Western blot. This antibody is not recommended for Western blot procedures and will not cross-react with bovine or rabbit.

Target Information

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.