Thermo Fisher Scientific CD171 (L1CAM) Chimeric Recombinant Rabbit Monoclonal Antibody (L1-14.10)
인간 L1CAM/CD171 단백질의 ectodomain을 인식하는 재조합 토끼 단클론 항체로, WB, IHC, ICC/IF, Flow, IP 등 다양한 어세이에 사용 가능. 높은 특이성과 순도, Protein A 정제, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | L1-14.10 |
| Immunogen | Recombinant L1-Fc fusion protein (ectodomain of human L1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_3074686 |
Product Specific Information
This antibody specifically recognizes the ectodomain (amino acids M1–E1123) of human L1, targeting an epitope in the third Ig domain.
L1 is over-expressed in various tumors including neuroblastomas, renal carcinomas, ovarian and endometrial carcinomas, and melanomas.
No cross-reactivity with human CHL1.
Target Information
L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin supergene family.
Its ectodomain consists of several immunoglobulin-like domains and fibronectin-like type III repeats, linked via a transmembrane sequence to a conserved cytoplasmic domain.
This cell adhesion molecule is critical for nervous system development, neuronal migration, and differentiation.
Mutations in the L1CAM gene cause X-linked neurological syndromes collectively known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia, hydrocephalus).
Alternative splicing of a neuron-specific exon is functionally relevant.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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