Thermo Fisher Scientific CD171 (L1CAM) Chimeric Recombinant Rabbit Monoclonal Antibody (L1-14.10)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody specifically recognizes the ectodomain (amino acids M1–E1123) of human L1, targeting an epitope in the third Ig domain.
L1 is over-expressed in various tumors including neuroblastomas, renal carcinomas, ovarian and endometrial carcinomas, and melanomas.
No cross-reactivity with human CHL1.

Target Information

L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin supergene family.
Its ectodomain consists of several immunoglobulin-like domains and fibronectin-like type III repeats, linked via a transmembrane sequence to a conserved cytoplasmic domain.
This cell adhesion molecule is critical for nervous system development, neuronal migration, and differentiation.
Mutations in the L1CAM gene cause X-linked neurological syndromes collectively known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia, hydrocephalus).
Alternative splicing of a neuron-specific exon is functionally relevant.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.