Thermo Fisher Scientific Phospho-Btk (Ser179) Polyclonal Antibody
인간 BTK 단백질의 Ser179 인산화 부위에 특이적인 Rabbit Polyclonal 항체. Western blot 및 Immunocytochemistry에 적합. 액상 형태로 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
- 카탈로그번호
- PA5118733
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-Btk (Ser179) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BTK around the phosphorylation site of Ser179 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2903233 |
Target Information
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases.
Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders.
It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9.
The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens.
BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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