Thermo Fisher Scientific CD230 (PrP) Monoclonal Antibody (2G11)
인간 CD230(PrP)에 특이적인 단클론 항체로, IHC 및 유세포분석에 사용 가능. 단백질 A로 정제된 액상 형태이며, 비결합형(Unconjugated)으로 제공. 인간 뇌조직에서 양성 대조로 사용되며, 프리온 단백질 연구에 적합.
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Thermo Fisher Scientific CD230 (PrP) Monoclonal Antibody (2G11)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Flow Cytometry (Flow) | 0.5–5 µg / 10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2G11 |
| Immunogen | Recombinant protein of human CD230 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Cerebrum tissue
- Cellular location: Membrane
Target Information
Human prion protein (PrP), also known as PRNP, is a GPI-anchored cell surface glycoprotein associated with lipid rafts and functions as a signaling molecule. PrP is involved in apoptosis, epithelial cell proliferation, and junction-associated protein distribution in enterocytes. Conversion of normal PrPc into the abnormal PrPSc conformer triggers prion neurodegenerative disorders such as Creutzfeld-Jakob disease (CJD). PrPc is rich in alpha-helices, while PrPSc has higher beta-sheet content and is resistant to proteinase K.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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