Thermo Fisher Scientific CD122 Monoclonal Antibody (TM-beta1)

Applications and Tested Dilutions

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2–10 µg/mL

Flow Cytometry (Flow)

• Tested Dilution: 0.5–5 µg/10⁶ cells

Product Specifications

Product Specific Information

• Positive control: Breast cancer
• Cellular location: Membrane

Target Information

CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses and is primarily expressed in the hematopoietic system. It exists in three forms:

• Low affinity form: Alpha subunit monomer, not involved in signal transduction
• Intermediate affinity form: Alpha/beta subunit heterodimer
• High affinity form: Alpha/beta/gamma subunit heterotrimer

The intermediate and high affinity forms mediate receptor endocytosis and mitogenic signal transduction.
The CD122 gene encodes the beta subunit, a type I membrane protein.
Dysfunction of CD122 is associated with oligoarticular juvenile idiopathic arthritis and rheumatoid factor negative juvenile idiopathic arthritis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.