ELK Biotechnology Claudin-7 (phospho Tyr210) rabbit pAb
Claudin-7 (phospho Tyr210) rabbit pAb는 인산화된 Claudin-7 단백질을 인식하는 폴리클로날 항체로, WB와 ELISA에 적합합니다. 세포막 및 타이트 접합 부위에 존재하는 단백질 검출에 유용하며, 다양한 암 연구에 활용 가능합니다.
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Claudin-7 (phospho Tyr210) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Claudin-7 (phospho Tyr210) rabbit pAb |
| Alternative Names | CLDN7; CEPTRL2; CPETRL2; Claudin-7; CLDN-7 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Claudin 7 around the phosphorylation site of Tyr210. AA range: 162-211 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 32 kD |
| GeneID (Human) | 1366 |
| Human Swiss-Prot No | O95471 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cell membrane; Multi-pass membrane protein; Basolateral cell membrane; Cell junction, tight junction; Co-localizes with EPCAM at the basolateral cell membrane and tight junction |
Background
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinoma, urinary tumors, prostate cancer, lung cancer, head and neck cancers, and thyroid carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, May 2010]
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