ELK Biotechnology MRP2 rabbit pAb
MRP2(ABCC2) 단백질을 인식하는 토끼 폴리클로날 항체로, WB와 ELISA에 적합합니다. 사람, 쥐, 랫드 시료에 반응하며, -20°C에서 1년 보관 가능합니다. 다약제 내성 관련 연구 및 간세포 담즙 수송 단백질 분석에 활용됩니다.
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MRP2 rabbit pAb
제품 개요
ELK Biotechnology의 MRP2 rabbit polyclonal antibody는 인간 ABCC2 유래 합성 펩타이드를 면역원으로 제작된 항체로, 다약제 내성 관련 단백질 MRP2를 검출하는 데 사용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | MRP2 rabbit pAb |
| Alternative Names | ABCC2; CMOAT; CMOAT1; CMRP; MRP2; Canalicular multispecific organic anion transporter 1; ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human ABCC2 (AA range: 991–1040) |
| Host | Rabbit |
| Storage | -20°C for 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 175 kDa |
| GeneID (Human) | 1244 |
| Human Swiss-Prot No | Q92887 |
| Cellular Localization | Apical cell membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intracellular membranes and are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
MRP2 belongs to the MRP subfamily, which is involved in multidrug resistance. It is expressed in the canalicular (apical) part of hepatocytes and functions in biliary transport. Substrates include anticancer drugs such as vinblastine, contributing to drug resistance in mammalian cells.
Mutations in this gene are associated with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
[provided by RefSeq, Jul 2008]
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