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ELK Biotechnology Chk1 (phospho Ser301) rabbit pAb
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Chk1 (phospho Ser301) rabbit pAb는 DNA 손상 반응과 세포 주기 조절 연구에 적합한 항체입니다. WB, IF, ELISA 등 다양한 응용에 사용 가능하며, 사람·마우스·랫트 시료에 반응합니다. 합성 인산화 펩타이드로 면역화된 고품질 폴리클로날 항체입니다.
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- pk
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ELK Biotechnology ES4595-100UL Chk1 (phospho Ser301) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES4595-50UL Chk1 (phospho Ser301) rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Chk1 (phospho Ser301) rabbit pAb
제품명
Chk1 (phospho Ser301) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CHEK1; CHK1; Serine/threonine-protein kinase Chk1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1 |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Chk1 around the phosphorylation site of Ser301 (AA range: 271–320) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kDa |
| Gene ID (Human) | 1111 |
| Human Swiss-Prot No. | O14757 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Nucleus, Chromosome, Cytoplasm, Cytoskeleton (microtubule organizing center, centrosome). Nuclear export mediated by XPO1/CRM1 (PubMed:12676962). Localizes to centrosome during interphase protecting CDC2 kinase from cytoplasmic CDC25B activation (PubMed:15311285). Proteolytic cleavage at C-terminus by SPRTN promotes chromatin removal (PubMed:31316063). |
Background
The protein encoded by this gene belongs to the Ser/Thr protein kinase family and is required for checkpoint-mediated cell cycle arrest in response to DNA damage or unreplicated DNA. It integrates signals from ATM and ATR, proteins involved in DNA damage responses and chromatin association during meiotic prophase I. Phosphorylation of CDC25A by this protein delays cell cycle progression upon DNA double-strand breaks. Several alternatively spliced transcript variants have been identified (RefSeq, Oct 2011).
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