Thermo Fisher Scientific PTPN2/TCPTP Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: Assay-dependent

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat

Target Information

T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins.
This enzyme has two C-terminal end splice variants with distinctly different subcellular localizations:

• The shorter 45 kDa isoform is exclusively nuclear in resting cells but redistributes to the cytosol upon stimulation with growth factors and cellular stress.
• The longer 48 kDa isoform is found in the endoplasmic reticulum and has distinct physiological substrates.

Although found in many cell types and tissues, TC-PTP is particularly prominent in hematopoietic cells. Knockout mice lacking TC-PTP die 3–5 weeks after birth due to erythropoietic and lymphopoietic deficits, indicating a critical role in bone marrow maturation.
TC-PTP dephosphorylates a wide range of phosphoproteins, including p52 Shc and receptors for EGF, insulin, and growth hormone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.