Thermo Fisher Scientific PTPN2/TCPTP Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. This enzyme has two C-terminal end splice variants with distinctly different subcellular localizations.
The 45 kDa isoform is nuclear in resting cells but redistributes to the cytosol upon stimulation with growth factors or stress. The 48 kDa isoform is localized in the endoplasmic reticulum and acts on different physiological substrates.
TC-PTP is highly expressed in hemopoietic cells. Knockout mice lacking TC-PTP die within 3–5 weeks due to erythropoietic and lymphopoietic defects, indicating its crucial role in bone marrow maturation. TC-PTP dephosphorylates various phosphoproteins, including p52 Shc and receptors for EGF, insulin, and growth hormone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.