Thermo Fisher Scientific PTPN2/TCPTP Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins.
This enzyme has two C-terminal splice variants with distinct subcellular localizations:

• The 45 kDa isoform is nuclear in resting cells and redistributes to the cytosol upon stimulation with growth factors or stress.
• The 48 kDa isoform is localized in the endoplasmic reticulum and appears to have different physiological substrates.

TC-PTP is abundant in hematopoietic cells. Knockout mice lacking TC-PTP die 3–5 weeks after birth due to erythropoietic and lymphopoietic deficits, indicating its essential role in bone marrow maturation. TC-PTP dephosphorylates a wide range of phosphoproteins, including p52 Shc and receptors for EGF, insulin, and growth hormone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.