Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI5F1), TrueMAB
인간 ABCB1 단백질을 표적으로 하는 마우스 단클론 항체로, Western blot에 적합합니다. TrueMAB 형식의 고품질 항체로 1 mg/mL 농도, PBS/BSA/glycerol 버퍼에 보존됩니다. 연구용으로 다중 약물 내성 관련 단백질 분석에 활용됩니다.
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Applications
- Western Blot (WB): Tested dilution 1:500
- Publications: None listed
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5F1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 995–1280 of human ABCB1 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters.
ABC proteins transport various molecules across extra- and intra-cellular membranes and are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein belongs to the MDR/TAP subfamily, which is involved in multidrug resistance.
The ABCB1 protein functions as an ATP-dependent drug efflux pump with broad substrate specificity, contributing to decreased drug accumulation in multidrug-resistant cells and mediating resistance to anticancer drugs.
It also acts as a transporter in the blood-brain barrier.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
제품 이미지
(해당 항체의 항원 구조 관련 이미지: TA801005_P-Glycoprotein_ABCB1_P08183-1_House_mouse.svg / TA801005_P-Glycoprotein_ABCB1_P08183-1_House_mouse_PDP.jpeg)
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