Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI3C8), TrueMAB
인간 ABCB1 단백질에 특이적인 단클론 항체로, IHC(P)에서 1:150 희석으로 검증됨. 항원은 인간 ABCB1의 995-1280 아미노산 영역. 액상 형태, 1 mg/mL 농도, PBS/BSA/글리세롤 버퍼에 보관. 다약제 내성 연구 및 P-glycoprotein 분석용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 995-1280 of human ABCB1 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.
ABC proteins transport various molecules across extra- and intra-cellular membranes.
ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MDR/TAP subfamily, involved in multidrug resistance.
It functions as an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity, responsible for decreased drug accumulation in multidrug-resistant cells and mediates resistance to anticancer drugs.
Additionally, it acts as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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