Thermo Fisher Scientific Caspase 1 p10 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Predicted reactivity: Mouse (80%), Rat (83%), Pig (81%)
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

Caspase-1 (CASP1)는 IL-1β를 Asp와 Ala 사이에서 절단하는 티올 프로테아제로, 성숙한 사이토카인의 방출을 유도하여 다양한 염증 반응에 관여합니다. 또한 SREBP를 절단 및 활성화하며, 세포사멸(apoptosis)을 촉진합니다. 인플라마좀 활성화 시, DNA 바이러스 감염 동안 CASP1은 CGAS 절단을 통해 항바이러스 면역을 조절합니다.

⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.