Thermo Fisher Scientific RED Polyclonal Antibody
Western blot, IHC, ICC/IF에 사용 가능한 Rabbit Polyclonal 항체로, Human RED 단백질(aa 251-480)에 특이적입니다. Antigen affinity chromatography로 정제되었으며, PBS buffer에 20% glycerol 포함. 4°C 단기, -20°C 장기 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to a region within amino acids 251–480 of Human RED |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.01 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2549624 |
Product Specific Information
- Recommended positive controls: 293T, A431, HepG2
- Predicted reactivity: Mouse (96%), Rat (96%), Chicken (87%), Rhesus Monkey (98%), Chimpanzee (99%), Bovine (97%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family. It is expressed during embryogenesis and in some malignancies.
IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present. It is expressed in a significantly higher proportion of melanomas than Spitz nevi and in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in regulating the biological behavior of this tumor.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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