Thermo Fisher Scientific HNF1A (Pancreatic Tumor Suppressor) Monoclonal Antibody (HNF1A, 2087)
HNF1A 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로 인간 시료에 반응합니다. IHC(P) 및 Peptide Array에 사용 가능하며, 고순도 Protein A/G 정제 형태로 제공됩니다. PBS 버퍼에 보존제 없이 액상 형태로 공급되며 연구용으로만 사용됩니다.
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- 6927-MSM2-P1ABX
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HNF1A, 2087 |
| Immunogen | Recombinant fragment (around aa 214–339) of human HNF1A protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C or –80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is tested in direct ELISA.
- For immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region and may play a role in the phenotype of WHS or Pitt-Rogers-Danks syndrome.
The encoded protein can react with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting potential use in specific immunotherapy for cancer patients. It is also known as a member of the NELF (negative elongation factor) protein complex, involved in regulation of RNA polymerase II transcription elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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