Thermo Fisher Scientific HNF1A (Pancreatic Tumor Suppressor) Monoclonal Antibody (HNF1A, 2087)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Peptide Array (Array)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

Immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

This gene is expressed ubiquitously, with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein.
Wolf-Hirschhorn syndrome (WHS) is associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region and may play a role in the phenotype of WHS or Pitt-Rogers-Danks syndrome.
The encoded protein can react with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting potential use in specific immunotherapy for various cancer patients.
It is also a member of the NELF (negative elongation factor) complex involved in RNA polymerase II transcription elongation regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.