Thermo Fisher Scientific KCNN2 Polyclonal Antibody
KCNN2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 및 비인간 영장류 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 면역조직화학(IHC) 적용 가능. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from C-terminus of human KCNN2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551243 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gorilla, Orangutan, Gibbon, Monkey (100%)
- Hamster, Panda, Dog, Horse, Guinea pig (94%)
- Marmoset, Rat, Elephant, Bat (89%)
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and influence neuronal firing patterns. Each AHP component is kinetically distinct and mediated by different calcium-activated potassium channels.
The KCNN2 gene product is activated before membrane hyperpolarization and regulates neuronal excitability by contributing to the slow component of synaptic AHP. It forms a voltage-independent calcium-activated channel with calmodulin-binding subunits. KCNN2 is part of the KCNN family of potassium channel genes, with two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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