Thermo Fisher Scientific ADAP Polyclonal Antibody

Thermo Fisher Scientific ADAP Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:500–1:3,000
Publications: -

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, Jurkat, Raji
• Predicted reactivity: Mouse (82%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion.
TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, activates the NF-kappa-B family of transcription factors.
Recent experiments show that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell–APC activation.
At least three isoforms of ADAP are known to exist.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.