Thermo Fisher Scientific IGF2BP3 Monoclonal Antibody (OTI4H5), TrueMAB
IGF2BP3 단백질을 인식하는 Mouse monoclonal 항체로 Western blot 및 IHC(P) 검증 완료. Human 시료에 반응하며, 1 mg/mL 농도의 액상 형태로 제공. Affinity chromatography로 정제되어 높은 특이성과 재현성 확보. 연구용으로 암 관련 단백질 발현 분석에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4H5 |
| Immunogen | Full length human recombinant protein of human IGF2BP3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family. It is expressed during embryogenesis and in certain malignancies.
IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present. It is found in a higher proportion of melanomas than Spitz nevi and is more prevalent in metastatic melanomas compared to thin melanomas. IMP-3 may play an important role in the progression and biological behavior regulation of malignant melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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