Thermo Fisher Scientific IGF2BP3 Monoclonal Antibody (OTI6A4), TrueMAB
IGF2BP3 단백질을 인식하는 Mouse Monoclonal 항체로 Western Blot 및 IHC(P) 검증 완료. 인간 시료에 반응하며, Affinity chromatography로 정제된 고순도 제품. 1 mg/mL 농도의 액상 형태로 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6A4 |
| Immunogen | Full length human recombinant protein of human IGF2BP3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies.
IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present. It is found in a significantly higher proportion of melanomas than Spitz nevi and is more abundant in metastatic melanomas than in thin melanomas.
IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in regulating the biologic behavior of this tumor.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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