Thermo Fisher Scientific MMP9 Polyclonal Antibody
Thermo Fisher Scientific의 MMP9 Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 MMP9 단백질 검출에 적합합니다. Western blot과 IHC(P)에서 검증되었으며, 항원 친화 크로마토그래피로 정제된 고순도 항체입니다. 연구용으로 조직 재형성 및 염증 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Raised against a 16 amino acid peptide near the center of human MMP9 (amino acids 260–310). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term); for long-term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890474 |
Product Specific Information
Positive controls that may be used include:
- Mouse Lung Tissue Lysate
- Human Lung Tissue Slide
Target Information
MMP9 (matrix metallopeptidase 9; also known as GELB, CLG4B) belongs to the matrix metalloproteinase family, which are zinc- and calcium-dependent endopeptidases responsible for degrading extracellular matrix proteins.
MMP9 is secreted as a 92 kDa zymogen, and upon cleavage, becomes an active 82 kDa enzyme. It features:
- A gelatin-binding domain with three fibronectin type II units
- A catalytic domain containing a zinc-binding site
- A proline-rich type V collagen-homologous domain
- A hemopexin-like domain
MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts, and endothelial cells, playing key roles in:
- Inflammatory responses
- Tissue remodeling and wound healing
- Tumor growth and metastasis
It degrades type IV and V collagens and is implicated in IL-8–induced mobilization of hematopoietic progenitor cells, tumor-associated tissue remodeling, idiopathic atrial fibrillation progression, and aortic aneurysm development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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