Thermo Fisher Scientific MMP9 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Positive controls that may be used include:

• Mouse Lung Tissue Lysate
• Human Lung Tissue Slide

Target Information

MMP9 (matrix metallopeptidase 9; also known as GELB, CLG4B) belongs to the matrix metalloproteinase family, which are zinc- and calcium-dependent endopeptidases responsible for degrading extracellular matrix proteins.
MMP9 is secreted as a 92 kDa zymogen, and upon cleavage, becomes an active 82 kDa enzyme. It features:

• A gelatin-binding domain with three fibronectin type II units
• A catalytic domain containing a zinc-binding site
• A proline-rich type V collagen-homologous domain
• A hemopexin-like domain

MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts, and endothelial cells, playing key roles in:

• Inflammatory responses
• Tissue remodeling and wound healing
• Tumor growth and metastasis

It degrades type IV and V collagens and is implicated in IL-8–induced mobilization of hematopoietic progenitor cells, tumor-associated tissue remodeling, idiopathic atrial fibrillation progression, and aortic aneurysm development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.