Thermo Fisher Scientific Cdc45L Polyclonal Antibody
Cdc45L 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot과 Immunocytochemistry에 적합하며, 인간에 반응하고 쥐·흰쥐·소에서 예측 반응성을 보임. 항원 친화 크로마토그래피로 정제된 액상 항체로, 연구용으로 사용.
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- PA522027
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 298–566 of CDC45L (Uniprot ID: O75419) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1 M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C (short term). For long term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11153008 |
Product Specific Information
- Recommended positive control: H1299
- Predicted reactivity: Mouse (93%), Rat (92%), Bovine (90%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene shows strong similarity to Saccharomyces cerevisiae Cdc45, an essential protein required for the initiation of DNA replication.
Cdc45 is part of a conserved multiprotein complex including Cdc6/Cdc18, MCMs, and DNA polymerase, crucial for early steps of DNA replication in eukaryotes.
It interacts with MCM7 and DNA polymerase alpha. Studies in Xenopus suggest that this protein plays a pivotal role in loading DNA polymerase alpha onto chromatin.
Multiple polyadenylation sites have been reported for this gene.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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