Thermo Fisher Scientific Protein C Polyclonal Antibody
Rabbit 폴리클로날 항체로 Human Protein C를 인식합니다. Western blot에 최적화되어 있으며, 1:500~1:3,000 희석 비율로 사용 가능합니다. 항원 친화 크로마토그래피로 정제되었고, 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 145–461 of Protein C (Uniprot ID: P04070) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11154119 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLa, Molt-4, Raji
- Predicted reactivity: Dog (82%), Rabbit (83%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. In its activated form, Protein C contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII.
Protein C is produced in the liver, composed of two polypeptide chains, and acts as a vitamin K-dependent serine protease. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor, and the active enzyme (55 kDa) cleaves factor Va and VIIIa to inhibit blood coagulation.
Normal plasma concentration of the active enzyme is approximately 1–3 ng/mL, while the proenzyme concentration is about 3 µg/mL.
Mutations in the Protein C gene are associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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