Thermo Fisher Scientific STAR Recombinant Rabbit Monoclonal Antibody (1Y5B4)
StAR 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF, ELISA에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 고순도의 액상 형태로 제공됩니다. 콜레스테롤 수송 관련 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:8,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:800 |
| Immunocytochemistry (ICC/IF) | 1:200–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1Y5B4 |
| Immunogen | Synthetic peptide corresponding to amino acids 100–200 of human StAR (NP_000340.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.09 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3094169 |
Product Specific Information
Immunogen sequence:
SQQDNGDKVM SKVVPDVGKV FRLEVVVDQP MERLYEELVE RMEAMGEWNP NVKEIKVLQK IGKDTFITHE LAAEAAGNLV GPRDFVSVRC AKRRGSTCVL A
Target Information
Steroidogenic acute regulatory protein (StAR) is essential for cholesterol transport from the outer to the inner mitochondrial membrane. The 37 kDa precursor is cleaved into an active 28 kDa protein that facilitates cholesterol conversion into pregnenolone. StAR is predominantly expressed in mitochondria of steroid-producing adrenal and gonadal tissues. Mutations in the StAR gene are associated with Lipoid Congenital Adrenal Hyperplasia (LCAH), leading to defects in pregnenolone and cortisol synthesis. The precise mechanism of cholesterol binding to StAR remains under investigation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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