Thermo Fisher Scientific PTPN2 Recombinant Rabbit Monoclonal Antibody (9J5P8)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD VSPYDHSRVK LQNAENDYIN ASLVDIEEAQ RSYILTQGPL PNTCCHFWLM VWQQKTKAVV MLNRIVEKES VKCAQYWPTD DQEMLFKETG FSVKLLSEDV KSYYTVHLLQ LENINSGETR TISHFHYTTW PDFGVPESPA SFLNFLFKVR ESGSLNPDHG PAVIHCSAGI GRSGTFSLVD TCLVLMEKGD DINIKQVLLN MRKYRMGLIQ TPDQLRFSYM AIIEGAKCIK GDSSIQKRWK ELSKEDLSPA FDHSPNKIMT EKYNGNRIGL EEEKLTGDRC TGLSSKMQDT MEENSERPRL TDT

Target Information

T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins.
This enzyme has two C-terminal end splice variants with distinctly different subcellular localizations:

• The shorter 45 kDa isoform is exclusively nuclear in resting cells but redistributes to the cytosol upon stimulation with growth factors and cellular stress.
• The longer 48 kDa isoform is found in the endoplasmic reticulum and has different physiologic substrates from the smaller isoform.

TC-PTP is prominent in hemopoietic cell types. Knockout mice lacking TC-PTP die within 3–5 weeks after birth due to erythropoietic and lymphopoietic deficits, indicating its critical role in bone marrow maturation.
It dephosphorylates a wide range of phosphoproteins, such as p52 Shc and receptors for EGF, Insulin, and growth hormone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.