Thermo Fisher Scientific MMP13 Monoclonal Antibody (OTI2D8), TrueMAB
인간 MMP13 단백질을 인식하는 단클론 항체로, Western blot, IHC, ICC/IF 등 다양한 응용에 사용 가능. 고순도 친화 크로마토그래피 정제, 무보존제 형태로 제공. 연구용으로 조직 재형성 및 골 발달 관련 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 104–471 of human MMP13 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
MMP13 (collagenase 3) is involved in the degradation of extracellular matrix proteins such as fibrillar collagen, fibronectin, tenascin-C (TNC), and aggrecan (ACAN).
It cleaves triple-helical collagens (type I, II, and III) with the highest activity against soluble type II collagen.
MMP13 also degrades collagen types IV, XIV, and X, and plays roles in wound healing, tissue remodeling, cartilage degradation, bone development, mineralization, and ossification.
Mutations in MMP13 are associated with skeletal disorders including spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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