Thermo Fisher Scientific GAPDH Polyclonal Antibody, HRP
GAPDH 단백질을 검출하기 위한 HRP 결합 토끼 폴리클로날 항체. Western blot에 최적화되어 있으며 인간, 마우스, 랫트 시료에 반응. 친화 크로마토그래피로 정제되었고, 4°C에서 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
- Publications: View 9 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide: V(126) M G V N H E K Y(140) |
| Conjugate | HRP |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.07% Kathon |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609746 |
Product Specific Information
By Western blot, PA1-987-HRP detects GAPDH at approximately 37 kDa band in human, mouse, and rat whole cell lysates.
Target Information
GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is a catalytic enzyme involved in glycolysis. It exists as a tetramer of identical 37-kDa subunits and catalyzes the reversible reduction of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphate in the presence of NADPH.
Beyond glycolysis, GAPDH is ubiquitously expressed and participates in multiple cellular processes including:
- DNA replication and repair
- Nuclear RNA export
- Membrane fusion and microtubule bundling
- Gene expression regulation in apoptosis
- Cellular mechanisms related to neurodegenerative diseases
GAPDH also interacts with amyloid precursor protein (linked to Alzheimer’s disease) and Huntingtin protein (linked to Huntington’s disease). Due to its high expression in most tissues, GAPDH serves as a reliable protein loading control in Western blot analysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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