Thermo Fisher Scientific SETD8 Monoclonal Antibody (B.540.4)
SETD8 단백질을 인식하는 Rabbit 모노클로날 항체로, Western blot과 Immunocytochemistry에 적합합니다. 인간, 마우스, 설치류 등 다양한 종에 반응하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific SETD8 Monoclonal Antibody (B.540.4)
Applications and Tested Dilution
- Western Blot (WB): 1:1,000
View 1 publication - Immunocytochemistry (ICC/IF): 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B.540.4 |
| Immunogen | Synthetic peptide corresponding to human SET8 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 25 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 50% glycerol, 100µg/mL BSA, 0.15M NaCl |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_11004382 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
SETD8 is a histone methyltransferase that specifically monomethylates Lys-20 of histone H4.
H4 Lys-20 monomethylation is enriched during mitosis and serves as a tag for epigenetic transcriptional repression.
SETD8 functions mainly in euchromatin regions, contributing to silencing of euchromatic genes and proper DNA structure maintenance during mitosis.
It also plays roles in chromosome condensation and cytokinesis. Nucleosomes are preferred substrates compared to free histones.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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