Thermo Fisher Scientific Estrogen Receptor Beta Monoclonal Antibody (PPZ0506)
ERβ에 특이적인 단클론 항체로, Western blot, IHC, ELISA, IP에 적합. 인간 및 마우스 시료 반응성. 비결합형 액상 포맷으로 제공되며 4°C 단기, -20°C 장기 보관 가능. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 6 publications |
| Immunohistochemistry (IHC) | – | View 2 publications |
| ELISA | 0.2 µg/mL | View reference |
| Immunoprecipitation (IP) | Assay-Dependent | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PPZ0506 |
| Immunogen | Estrogen Receptor beta antibody for 2–88 amino acid peptide in human ER beta. Ligand for estrogenic 17β-estradiol compound. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | Physiological saline |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2717280 |
Product Specific Information
This antibody specifically recognizes human ER beta but does not recognize human ER alpha.
Target Information
Estrogen Receptor beta (ERβ, NR3A2) is approximately 55 kDa, with multiple isoforms ranging from 36–59 kDa. Human ERβ was first cloned from testis and belongs to the steroid/thyroid hormone receptor superfamily of nuclear receptors.
ERs are ligand-activated transcription factors that, upon binding estrogen, undergo conformational changes allowing dimerization and binding to estrogen response elements (EREs) in DNA. This binding regulates gene transcription through coactivator or corepressor recruitment.
There are two forms of estrogen receptor, alpha (ESR1) and beta (ESR2). ERβ binds estrogens with similar affinity to ERα, and certain ERβ isoforms can inhibit ERα activity in reproductive tissues.
ERβ is widely distributed in various tissues and functions as a tumor suppressor, implicated in prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain disease, and cardiovascular disease risk.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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