Thermo Fisher Scientific ADAMTS7 Polyclonal Antibody
인간 ADAMTS7 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체로, 장기 보관 시 -20°C에서 안정적. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ADAMTS7. Recombinant protein control fragment (Product #RP-102975) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2637671 |
Product Specific Information
- Immunogen sequence: LGRAHIRAHT PACHLLGEVQ DSELEGGLAA ISACDGLKGV FLLSN
- Highest antigen sequence identity to orthologs: Mouse - 76%, Rat - 71%
Target Information
ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) is a family of zinc-dependent proteases involved in various normal and pathological processes, including arthritis and cancer.
These proteins contain:
- N-terminal propeptide domain
- Metalloproteinase domain
- Disintegrin-like domain
- C-terminal region with variable thrombospondin type-1 (TSP-1) motifs
ADAMTS genes are mainly expressed in fetal tissues such as lung, kidney, and liver.
ADAMTS-7 (also known as COMPase) is a 1,686 amino acid protein with two alternatively spliced isoforms, encoded by a gene on human chromosome 15q25.1.
It contains eight TSP-1 motifs and binds one zinc ion per subunit.
Expression: Heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, meniscus, bone, tendon, cartilage, synovium, fat, and ligaments.
Function: Metalloprotease involved in COMP degradation; up-regulated in articular cartilage and synovium of arthritis patients.
Optimum pH: 7.5–9.5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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