Thermo Fisher Scientific Arg3.1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
• The peptide is homologous in rat and mouse.
• Specificity: Arg3.1/ARC.

Target Information

Arg3.1 (ARC) is a master regulator of synaptic plasticity that self-assembles into virion-like capsids encapsulating RNAs and mediating intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles, transferring ARC mRNA into new target cells where it undergoes activity-dependent translation. ARC capsids are endocytosed and transfer ARC mRNA into neuronal cytoplasm.

It acts as a key regulator of synaptic plasticity, required for protein synthesis-dependent long-term potentiation (LTP) and depression (LTD), and long-term memory formation. ARC promotes endocytosis of AMPA receptors (AMPARs) in response to synaptic activity, maintaining surface AMPAR levels through synaptic scaling and contributing to neuronal homeostasis.

ARC mediates activity-dependent synapse elimination in developing cerebellum, accumulates at weaker synapses to prevent undesired enhancement, and is essential for visual cortex plasticity and long-term memory. Additionally, ARC is involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via PSEN1 interaction, and plays roles in immune regulation, particularly in skin-migratory dendritic cells that modulate T-cell activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.