Thermo Fisher Scientific Arg3.1 Polyclonal Antibody
Arg3.1/ARC 단백질을 인식하는 sheep polyclonal IgG 항체로, WB 및 IHC에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 합성 펩타이드 항원을 사용해 제작되었습니다. 장기 보관 시 -20°C에서 냉동 보관하며 연구용으로만 사용됩니다.
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- OSA00014G-500UG
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from human Arg3.1 (ARC) conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity: Arg3.1/ARC.
Target Information
Arg3.1 (ARC) is a master regulator of synaptic plasticity that self-assembles into virion-like capsids encapsulating RNAs and mediating intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles, transferring ARC mRNA into new target cells where it undergoes activity-dependent translation. ARC capsids are endocytosed and transfer ARC mRNA into neuronal cytoplasm.
It acts as a key regulator of synaptic plasticity, required for protein synthesis-dependent long-term potentiation (LTP) and depression (LTD), and long-term memory formation. ARC promotes endocytosis of AMPA receptors (AMPARs) in response to synaptic activity, maintaining surface AMPAR levels through synaptic scaling and contributing to neuronal homeostasis.
ARC mediates activity-dependent synapse elimination in developing cerebellum, accumulates at weaker synapses to prevent undesired enhancement, and is essential for visual cortex plasticity and long-term memory. Additionally, ARC is involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via PSEN1 interaction, and plays roles in immune regulation, particularly in skin-migratory dendritic cells that modulate T-cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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