Thermo Fisher Scientific ATG4C Polyclonal Antibody
ATG4C 단백질을 인식하는 Thermo Fisher Scientific의 Sheep 폴리클로날 항체입니다. Western blot 및 IHC에 사용 가능하며, 인간, 마우스, 랫트 반응성을 가집니다. 자가포식 관련 연구에 적합하며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Thermo Fisher Scientific ATG4C Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 10–50 µg/mL |
| Immunohistochemistry (IHC) | 10–50 µg/mL |
| Miscellaneous PubMed (Misc) | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from human cysteine protease ATG4C (autophagin-3, APG4C, AUTL1, AUTL3) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: ATG4C.
Target Information
ATG4C is involved in autophagy, the process by which endogenous proteins and damaged organelles are degraded intracellularly. Autophagy is essential for cell homeostasis and remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced autophagy has been observed in certain malignant tumors, suggesting a role in controlling unregulated cell growth linked to cancer.
ATG4C encodes a member of the autophagin protein family and the C-54 cysteine protease family. It cleaves the C-terminal part of MAP1LC3, GABARAPL2, or GABARAP, enabling liberation of form I, which is subsequently converted to form II, the phosphatidylethanolamine (PE)-conjugated form capable of binding autophagosomes. Highly expressed in skeletal muscle, heart, liver, and testis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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