Thermo Fisher Scientific Activin A Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Goat Polyclonal Activin A 항체. Western blot, IHC, ICC/IF, Neutralization 등 다양한 응용 가능. CHO 유래 recombinant Activin A를 면역원으로 사용. 항원 친화 크로마토그래피로 정제된 동결건조 형태의 항체.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–15 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 5–25 µg/mL | - |
| Neutralization (Neu) | 2–6 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CHO-derived recombinant human Activin A |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609618 |
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
Activins are dimeric growth and differentiation factors belonging to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins.
They signal through a heteromeric complex of receptor serine kinases, including at least two type I (I and IB) and two type II (II and IIB) receptors.
These receptors are transmembrane proteins composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity.
Type I receptors are essential for signaling, while type II receptors are required for ligand binding and expression of type I receptors.
After ligand binding, type I and II receptors form a stable complex, leading to phosphorylation of type I receptors by type II receptors.
Mutations in Activin A are associated with fibrodysplasia ossificans progressiva.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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