Thermo Fisher Scientific ALK Monoclonal Antibody (OTI1B2), TrueMAB
ALK 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 Immunocytochemistry에 사용 가능. 인간 ALK 재조합 단백질로부터 유래된 면역원 사용. 1 mg/mL 농도의 액상 형태로, PBS/BSA/glycerol buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B2 |
| Immunogen | Full length human recombinant protein of human ALK produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is essential for brain development. Mutations, rearrangements, and amplifications in the ALK gene are associated with several tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. The most common alteration is chromosomal rearrangement, producing a fusion gene between ALK and the nucleophosmin (NPM) gene. The resulting NPM-ALK fusion protein is oncogenic. ALK encodes a receptor tyrosine kinase with a transmembrane and extracellular domain, showing high similarity to LTK, and plays a crucial role in neuronal development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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