Thermo Fisher Scientific ALK Monoclonal Antibody (OTI7E11), TrueMAB
인간 ALK 단백질을 표적으로 하는 Mouse IgG2b 단클론 항체로, Western blot에 적합. 1 mg/mL 농도의 액상 제품이며, 친화 크로마토그래피로 정제됨. 뇌 발달 및 종양 관련 연구용으로 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7E11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1060–1620 of human ALK produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. Chromosomal rearrangement commonly creates a fusion gene between ALK and nucleophosmin (NPM). The NPM-ALK fusion product is oncogenic. ALK is a receptor protein-tyrosine kinase with transmembrane and extracellular domains, which are absent in the NPM-ALK product. ALK shows high sequence similarity to LTK and plays an important role in brain development, affecting specific neurons in the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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