Thermo Fisher Scientific FMR1 Monoclonal Antibody (OTI2C3), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

• For reconstitution, add 100 µL distilled water to obtain approximately 1 mg/mL antibody concentration.
• For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

FMR1 binds RNA and associates with polysomes. It may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat in the 5′ UTR normally contains 6–53 copies; expansion to 55–230 repeats causes fragile X syndrome. Repeat expansion may also lead to premature ovarian failure. Multiple alternatively spliced transcript variants encoding different isoforms located in distinct cellular compartments have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.