Thermo Fisher Scientific mGluR5 Recombinant Rabbit Monoclonal Antibody (ARC0250)
mGluR5 단백질을 표적하는 재조합 토끼 단클론 항체로, Mouse 및 Rat 시료에 반응합니다. Western blot과 ELISA에 적합하며, 높은 특이성과 재현성을 제공합니다. HEK293 세포에서 발현되었으며, 액상 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0250 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1100–1200 of human GRM5 (P41594) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898015 |
Product Specific Information
- Positive Samples: Mouse brain
- Immunogen sequence:
PKEIQLPTTM TTFAEIQPLP AIEVTGGAQP AAGAQAAGDA ARESPAAGPE AAAAKPDLEE LVALTPPSPF RDSVDSGSTT PNSPVSESAL CIPSSPKYDT L
Target Information
GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of the Serine/Threonine kinase family.
GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein-mediated phosphorylation promotes arrestin binding, which removes the receptor from the G-protein and terminates the receptor signal chain.
GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 can be inhibited by recoverin, a calcium-binding protein.
Diseases associated with GRK1 dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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