Thermo Fisher Scientific Beta-catenin Polyclonal Antibody
Beta-catenin 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP 등 다양한 응용에 사용 가능. 인간 유래 항원(710-760 aa)에 대해 제작되었으며, 4°C에서 보관. 세포 접착 및 신호전달 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 710 and 760 of human beta-catenin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Predicted to react with Rat, X. laevis, Bovine, and Dog (based on 100% sequence identity)
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and regulation of epithelial layer formation. It interacts with E-cadherin and alpha-catenin to anchor the E-cadherin complex to the actin cytoskeleton. Beta-catenin also associates with the adenomatous polyposis coli protein and microtubules, participating in signaling pathways involving tyrosine kinases, phosphatases, and Wnt/Wingless.
In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors that regulate genes such as cyclin D and c-myc, promoting cell proliferation. Dysregulation of beta-catenin is implicated in various cancers including colorectal, ovarian, breast, liver, lung, gastric, prostate, and skin tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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