Thermo Fisher Scientific P-Selectin Recombinant Rabbit Monoclonal Antibody (001)

Applications and Tested Dilution

Product Specifications

Additional Formats

• HRP Conjugated Version
• Request Custom Conjugation

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal clones for production.
Advantages include:

• Superior specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody specifically recognizes Human SELP/P Selectin.

Target Information

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type I transmembrane glycoprotein involved in cell rolling regulation. It is stored in Weibel-Palade bodies of endothelial cells and α-granules of platelets, and rapidly translocates to the cell surface upon activation by thrombin, histamine, complement 5a, Ca²⁺ ionophores, or ADP.
P-selectin mediates interactions between activated endothelial cells or platelets and leukocytes, playing a crucial role in adhesion processes and inflammation. It binds to sialylated Lewis carbohydrate antigens on neutrophils and monocytes, contributing to atherogenesis, thrombosis, and tissue destruction. Clinically, P-selectin is used to differentiate heparin-induced thrombocytopenia with or without thrombosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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