Thermo Fisher Scientific SPP1 Monoclonal Antibody (OTI5E4), TrueMAB
인간 Osteopontin(SPP1)을 인식하는 Mouse IgG1 단클론 항체로, WB 및 IHC(P)에서 검증됨. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도 유지. 세포 부착, 이동, 염증 및 종양 관련 연구에 적합. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5E4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 17–314 of human SPP1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It plays roles in bone mineralization, cell adhesion, migration, chronic inflammation, and tumor transformation.
Proteolytic cleavage by thrombin and matrix metalloproteinases near the integrin-binding RGD sequence modulates its function.
Thrombin-cleaved fragments are overexpressed in malignant glial tumors, providing a survival advantage and serving as substrates for plasmin and cathepsin D.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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