Thermo Fisher Scientific PROZ Monoclonal Antibody (OTI4D5), TrueMAB

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

PROZ (Protein Z) is a vitamin K–dependent plasma glycoprotein of approximately 62 kDa and 396 amino acids. It contains four domains: a gla-rich region, two EGF-like domains, and a trypsin-like domain. Although structurally related to serine proteases of the coagulation cascade (factors VII, IX, X, and protein C), it lacks the catalytic serine residue. Protein Z binds phospholipid surfaces via carboxyglutamate residues and enhances degradation of factor Xa by protein Z-related protease inhibitor (ZPI), accelerating the reaction about 1000-fold. Deficiency states have been variably associated with thrombosis or bleeding tendencies. Its function is vitamin K–dependent and can be impaired by warfarin therapy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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