Thermo Fisher Scientific SPP1 Monoclonal Antibody (OTI3C4), TrueMAB
Human SPP1(Osteopontin) 단백질을 인식하는 Mouse IgG2b 단클론 항체. Western blot에 1:500 희석으로 사용 가능. 동결건조 형태로 제공되며, PBS 버퍼에 trehalose 포함. 연구용으로 세포 부착, 이동 및 염증 관련 단백질 분석에 적합.
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Applications
- Western Blot (WB): Tested Dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 17–314 of human SPP1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
- For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Osteopontin (SPP1) is an RGD-containing glycoprotein that interacts with integrins and CD44 as major receptors. It plays roles in bone mineralization, cell adhesion, migration, chronic inflammatory disease, and cellular transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases near the RGD sequence modulates its integrin-binding properties. Thrombin-cleaved fragments are overexpressed in malignant glial tumors, contributing to tumor survival and providing substrates for plasmin and cathepsin D.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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