Thermo Fisher Scientific Cyclophilin B Recombinant Rabbit Monoclonal Antibody (ARC0290)
Cyclophilin B 단백질을 인식하는 토끼 단클론 항체로, Western blot 및 ELISA에 적합합니다. HEK293 세포에서 발현된 재조합 항체이며, 높은 특이성과 재현성을 제공합니다. 연구용으로 면역억제 관련 단백질 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0290 |
| Immunogen | Synthetic peptide corresponding to amino acids 100–200 of human Cyclophilin B (P23284) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849491 |
Product Specific Information
Immunogen sequence:
FMIQGGDFTR GDGTGGKSIY GERFPDENFK LKHYGPGWVS MANAGKDTNG SQFFITTVKT AWLDGKHVVF GKVLEGMEVV RKVESTKTDS RDKPLKDVII A
Target Information
Immunophilins are a family of soluble cytosolic receptors capable of binding to immunosuppressant agents such as cyclosporin A (CsA) or FK506. Proteins binding FK506 are termed FK506 Binding Proteins (FKBPs), and those binding cyclosporin A are called cyclophilins (CyPs).
Both CyP:CsA and FKBP:FK506 complexes inhibit calcineurin, a calcium- and calmodulin-dependent protein phosphatase involved in T-cell activation, providing a mechanism for immunosuppression.
Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIases), accelerating protein folding by catalyzing slow proline rearrangement steps.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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