Thermo Fisher Scientific PAX2 (Renal Cell and Ovarian Carcinoma Marker) Monoclonal Antibody (PAX2/1104)
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PAX2 단백질을 표적하는 단일클론 항체로, 신장세포암 및 난소암 조직의 면역조직화학(IHC) 분석에 적합합니다. 인간 시료 반응성이 있으며, Protein A/G로 정제된 액상 형태입니다. 4°C 보관, 동결 금지. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| ELISA | Assay-dependent |
| Peptide Array | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PAX2/1104 |
| Immunogen | Recombinant fragment (around aa 223–354) of human PAX2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The PAX gene family encodes transcription factors active in specific tissues during early embryonic development. Members of this family contain a paired box DNA-binding domain and regulate genetic programs essential for organogenesis.
- PAX2 is expressed in developing kidney tissues, particularly in condensing metanephric mesenchyme and early epithelial structures.
- Expression is downregulated as the renal tubular epithelium matures but persists in Wilms’ tumors, correlating with poorly differentiated epithelial proliferation.
- Mutations or dysregulation of PAX genes are linked to developmental disorders such as Waardenburg syndrome (PAX3) and Aniridia (PAX6).
- The Wilms’ tumor suppressor protein WT1 appears to repress PAX2 transcription during normal differentiation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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