Thermo Fisher Scientific Phospho-LAT (Tyr200) Polyclonal Antibody
LAT 단백질의 Tyr200 인산화 형태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot과 IHC(Paraffin)에 적합하며, 인간과 생쥐 시료에서 반응. PBS/glycerol buffer에 보관, -20°C에서 안정적 유지.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LAT (Accession O43561), corresponding to amino acid residues around phosphorylated Tyr200. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816083 |
Product Specific Information
This antibody detects endogenous levels of LAT only when phosphorylated at Tyr200.
Target Information
LAT (Linker for Activation of T cells) is a 36–38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells, and platelets. Upon immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell and FcεRI-dependent mast cell activation, as well as for maturation of early thymocytes. It also plays roles in NK cell signaling and platelet activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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