Thermo Fisher Scientific TIM3/HAVCR2/ CD366 (Effector T-Cell Marker) Monoclonal Antibody (TIM3/4024)
Effector T-세포 마커 TIM3/HAVCR2/CD366를 인식하는 Mouse monoclonal antibody. Western blot 및 Immunohistochemistry에 적합. Recombinant human TIM3 fragment(aa 22-202)를 면역원으로 사용. 단백질 A/G 정제, PBS buffer, 무보존제, -20°C 보관.
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Thermo Fisher Scientific TIM3/HAVCR2/CD366 (Effector T-Cell Marker) Monoclonal Antibody (TIM3/4024)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TIM3/4024 |
| Immunogen | Recombinant fragment of human TIM3 protein (around aa 22–202) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid long, Type-1 Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
It consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 is involved in macrophage activation and induction of autoimmune diseases. It down-regulates aggressive Th1-mediated immune responses and facilitates immune tolerance.
Pathological significance includes experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, which TIM3 enhances in severity in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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