Thermo Fisher Scientific CD26 Monoclonal Antibody (BA5b)

Applications

Flow Cytometry (Flow)

• Tested Dilution: 1–2 µg/mL

Product Specifications

Additional Formats

• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of CD26, a 110 kDa type II transmembrane glycoprotein, which is a peptidase expressed on mature thymocytes, T cells (especially activated), B cells, NK cells, and macrophages.

Target Information

CD26 (dipeptidyl peptidase IV, DPP IV; adenosine deaminase binding protein) is a homodimeric atypical serine protease belonging to the prolyl oligopeptidase family.
It is expressed on lymphocytes and upregulated during T-cell activation, also found on activated B cells, NK cells, and epithelial tissues.

CD26 participates in:

• T-cell activation
• Cell adhesion with extracellular matrix (fibronectin, collagens)
• HIV infection mechanisms

It is identical to adenosine deaminase complexing protein-2 and functions as a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides.
Altered CD26 activity is linked to malignant transformation and tumor progression. Changes in CD26 density are also observed in monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.