Thermo Fisher Scientific PTK2 Monoclonal Antibody (OTI4A8), TrueMAB
Human PTK2(Focal Adhesion Kinase, FAK)에 특이적인 mouse monoclonal antibody. Western blot, IHC, ICC/IF 등에 적합. Lyophilized 형태로 제공되며, 1 mg/mL 농도. 세포 부착 및 신호전달 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4A8 |
| Immunogen | Full length human recombinant protein of human PTK2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to reach a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of integrin signaling.
FAK plays an important role in cell spreading, differentiation, migration, cell death, and cell cycle progression from G1 to S phase.
It localizes to focal adhesions, mediating attachment to the extracellular matrix via integrin receptors.
Tyrosine phosphorylation of FAK increases upon integrin engagement with fibronectin, promoting association with Grb2 and c-Src PTK, and activating ERK2 MAP kinase.
The Grb2 SH2 domain binds directly to tyrosine-phosphorylated FAK at Tyr925.
Several transcript variants exist for the FAK gene, with three full-length forms characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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