Thermo Fisher Scientific PTK2 Monoclonal Antibody (OTI4A8), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to reach a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of integrin signaling.
FAK plays an important role in cell spreading, differentiation, migration, cell death, and cell cycle progression from G1 to S phase.
It localizes to focal adhesions, mediating attachment to the extracellular matrix via integrin receptors.
Tyrosine phosphorylation of FAK increases upon integrin engagement with fibronectin, promoting association with Grb2 and c-Src PTK, and activating ERK2 MAP kinase.
The Grb2 SH2 domain binds directly to tyrosine-phosphorylated FAK at Tyr925.
Several transcript variants exist for the FAK gene, with three full-length forms characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.